DENATONIUM AS A BITTER TASTE RECEPTOR AGONIST MODIFIES TRANSCRIPTOMIC PROFILE AND FUNCTIONS OF ACUTE MYELOID LEUKEMIA CELLS

Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells

The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest.Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a Shelving central warning signal to induce aversion toward noxious or harmful substances.Nevertheless, the increasing amount of evi

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Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis

ABSTRACT Constitutive biosynthesis of lipid A via the Raetz pathway is essential for the viability and fitness of Gram-negative bacteria, including Chlamydia trachomatis.Although nearly all of the enzymes in the lipid A biosynthetic pathway are highly conserved across Gram-negative bacteria, the cleavage of the pyrophosphate group of UDP-2,3-diacyl

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Early brain-body impact of emotional arousal

Current research in affective neuroscience suggests that the emotional content of visual stimuli activates brain–body responses that could be critical to general health and physical disease.The aim of this study was to IGORA VARIO BLONDE develop an integrated neurophysiological approach linking central and peripheral markers of nervous activi

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